Alu Elements and Human Disease
نویسنده
چکیده
The Alu element Methylation of Alu Repeats DNA Demethylation Mechanism of Retrotransposition Alu elements and Disease Conclusion and Outlook Endnotes
منابع مشابه
Structural Variation of Alu Element and Human Disease
Transposable elements are one of major sources to cause genomic instability through various mechanisms including de novo insertion, insertion-mediated genomic deletion, and recombination-associated genomic deletion. Among them is Alu element which is the most abundant element, composing ~10% of the human genome. The element emerged in the primate genome 65 million years ago and has since propag...
متن کاملRecent insertion of an Alu element within a polymorphic human-specific Alu insertion.
Alu elements are a family of short interspersed repeats that have mobilized throughout primate genomes by retrotransposition over the past 65 Myr of primate evolution (for a review, see Deininger and Batzer 1993). In the human genome, Alu elements exist in copy numbers of approximately 500,000 per haploid genome, representing approximately 5% of the genome, and they may be classified into group...
متن کاملAn Alu element retroposition in two families with Huntington disease defines a new active Alu subfamily.
Alu repetitive elements represent the most common short interspersed elements (SINEs) found in primates, with an estimated 500,000 members in the haploid human genome. Considerable evidence has accumulated that these elements have dispersed in the genome by active transcription followed by retroposition, and that this process is ongoing. Sequence variation between the individual elements has le...
متن کاملActive Alu element "A-tails": size does matter.
Long and short interspersed elements (LINEs and SINEs) are retroelements that make up almost half of the human genome. L1 and Alu represent the most prolific human LINE and SINE families, respectively. Only a few Alu elements are able to retropose, and the factors determining their retroposition capacity are poorly understood. The data presented in this paper indicate that the length of Alu "A-...
متن کاملAlu insertion polymorphisms for the study of human genomic diversity.
Genomic database mining has been a very useful aid in the identification and retrieval of recently integrated Alu elements from the human genome. We analyzed Alu elements retrieved from the GenBank database and identified two new Alu subfamilies, Alu Yb9 and Alu Yc2, and further characterized Yc1 subfamily members. Some members of each of the three subfamilies have inserted in the human genome ...
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تاریخ انتشار 2007